USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P30038 USC-OGP 2-DE database:  P30038 P30038 General information about the entry View entry in simple text format Entry name AL4A1_HUMAN Primary accession number P30038 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Short=P5C dehydrogenase; EC=1.2.1.88; AltName: Full=Aldehyde dehydrogenase family 4 member A1; AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase; Flags: Precursor;. Gene name Name=ALDH4A1 Synonyms=ALDH4, P5CDH Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0582: pI=5.40; Mw=17844 Cross-references UniProtKB/Swiss-Prot P30038; AL4A1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name AL4A1_HUMAN Primary accession number P30038 Secondary accession number(s) A8K1Q7 B4DGE4 D2D4A3 Q16882 Q53HU4 Q5JNV6 Q8IZ38 Q96IF0 Q9UDI6 Sequence was last modified on  February 1, 2005 (version 3) Annotations were last modified on  March 15, 2017 (version 181) Name and origin of the protein Description RecName: Full=Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Short=P5C dehydrogenase; EC=1.2.1.88; AltName: Full=Aldehyde dehydrogenase family 4 member A1; AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase; Flags: Precursor; Gene name Name=ALDH4A1 Synonyms=ALDH4, P5CDH Encoded on Name=ALDH4A1; Synonyms=ALDH4, P5CDH Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Proline metabolism; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U24267; AAC50501.1; -; mRNA EMBL U24266; AAC50500.1; -; mRNA EMBL FJ462711; ACN89883.1; -; mRNA EMBL AK289972; BAF82661.1; -; mRNA EMBL AK294552; BAG57755.1; -; mRNA EMBL AK222486; BAD96206.1; -; mRNA EMBL AL080251; CAI23417.1; -; Genomic_DNA EMBL AL954340; CAI23417.1; JOINED; Genomic_DNA EMBL AL954340; CAI39493.1; -; Genomic_DNA EMBL AL080251; CAI39493.1; JOINED; Genomic_DNA EMBL BX537160; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471134; EAW94858.1; -; Genomic_DNA EMBL BC007581; AAH07581.1; -; mRNA EMBL BC023600; AAH23600.1; -; mRNA CCDS CCDS188.1; -. [P30038-1]; . CCDS CCDS53272.1; -. [P30038-2]; . CCDS CCDS81273.1; -. [P30038-3]; . RefSeq NP_001154976.1; NM_001161504.1. [P30038-2]; . RefSeq NP_001306147.1; NM_001319218.1. [P30038-3]; . RefSeq NP_003739.2; NM_003748.3. [P30038-1]; . RefSeq NP_733844.1; NM_170726.2. [P30038-1]; . UniGene Hs.77448; -; . PDB 3V9G; X-ray; 2.50 A; A/B/C/D=18-563 PDB 3V9H; X-ray; 2.40 A; A/B/C/D=18-563 PDB 3V9I; X-ray; 2.85 A; A/B/C/D=18-563 PDB 4OE5; X-ray; 1.95 A; A/B/C/D=18-563 PDBsum 3V9G; -; . PDBsum 3V9H; -; . PDBsum 3V9I; -; . PDBsum 4OE5; -; . ProteinModelPortal P30038; -; . SMR P30038; -; . BioGrid 114208; 23; . IntAct P30038; 2; . STRING 9606.ENSP00000290597; -; . ChEMBL CHEMBL3414418; -; . DrugBank DB00157; NADH; . iPTMnet P30038; -; . PhosphoSitePlus P30038; -; . BioMuta ALDH4A1; -; . DMDM 62511241; -; . OGP P30038; -; . SWISS-2DPAGE P30038; -; . EPD P30038; -; . MaxQB P30038; -; . PaxDb P30038; -; . PeptideAtlas P30038; -; . PRIDE P30038; -; . DNASU 8659; -; . Ensembl ENST00000290597; ENSP00000290597; ENSG00000159423. [P30038-1]; . Ensembl ENST00000375341; ENSP00000364490; ENSG00000159423. [P30038-1]; . Ensembl ENST00000538309; ENSP00000442988; ENSG00000159423. [P30038-2]; . Ensembl ENST00000538839; ENSP00000446071; ENSG00000159423. [P30038-3]; . GeneID 8659; -; . KEGG hsa:8659; -; . UCSC uc001bbb.4; human. [P30038-1]; . CTD 8659; -; . DisGeNET 8659; -; . GeneCards ALDH4A1; -; . HGNC HGNC:406; ALDH4A1; . HPA CAB004645; -; . HPA HPA006401; -; . MalaCards ALDH4A1; -; . MIM 239510; phenotype; . MIM 606811; gene; . neXtProt NX_P30038; -; . OpenTargets ENSG00000159423; -; . Orphanet 79101; Hyperprolinemia type 2; . PharmGKB PA24701; -; . eggNOG KOG2455; Eukaryota; . eggNOG COG1012; LUCA; . GeneTree ENSGT00560000077335; -; . HOVERGEN HBG050484; -; . InParanoid P30038; -; . KO K00294; -; . OMA KIWEKAA; -; . OrthoDB EOG091G085N; -; . PhylomeDB P30038; -; . TreeFam TF300481; -; . BioCyc MetaCyc:HS14757-MONOMER; -; . BRENDA 1.2.1.88; 2681; . Reactome R-HSA-70688; Proline catabolism; . SABIO-RK P30038; -; . UniPathway UPA00261; UER00374; . ChiTaRS ALDH4A1; human; . GeneWiki Aldehyde_dehydrogenase_4_family; _member_A1; -; . GenomeRNAi 8659; -; . PRO PR:P30038; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000159423; -; . CleanEx HS_ALDH4A1; -; . ExpressionAtlas P30038; baseline and differential; . Genevisible P30038; HS; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; EXP:Reactome; . GO GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:CACAO; . GO GO:0009055; F:electron carrier activity; TAS:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0019470; P:4-hydroxyproline catabolic process; TAS:BHF-UCL; . GO GO:0006537; P:glutamate biosynthetic process; IEA:InterPro; . GO GO:0006561; P:proline biosynthetic process; IEA:InterPro; . GO GO:0006562; P:proline catabolic process; TAS:Reactome; . GO GO:0010133; P:proline catabolic process to glutamate; IEA:UniProtKB-UniPathway; . GO GO:0006560; P:proline metabolic process; TAS:ProtInc; . CDD cd07123; ALDH_F4-17_P5CDH; 1; . Gene3D 3.40.309.10; -; 1; . Gene3D 3.40.605.10; -; 1; . InterPro IPR016161; Ald_DH/histidinol_DH; . InterPro IPR016163; Ald_DH_C; . InterPro IPR016160; Ald_DH_CS_CYS; . InterPro IPR029510; Ald_DH_CS_GLU; . InterPro IPR016162; Ald_DH_N; . InterPro IPR015590; Aldehyde_DH_dom; . InterPro IPR005931; P5CDH/ALDH4A1; . Pfam PF00171; Aldedh; 1; . SUPFAM SSF53720; SSF53720; 1; . TIGRFAMs TIGR01236; D1pyr5carbox1; 1; . PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1; . PROSITE PS00687; ALDEHYDE_DEHYDR_GLU; 1; .

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